Haematology – Sickle Cell Open Education

Haemoglobin structures

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Content Author:
Dr Mark Fowler

Level:
Undergraduate bioscience or medical student.

OER Features:

SCOOTER109a_Deoxyhaemoglobin PPT

SCOOTER109b_Deoxyhaemoglobin PDF

SCOOTER110a_DeoxyhaemoglobinS PPT

SCOOTER110b_Deoxyhaemoglobin S PDF

OER Description:

Here are some deoxyhaemoglobin molecules constructed using Jmol – an open-source Java viewer for 3D chemical structures. You can access Jmol here:

http://jmol.sourceforge.net

The images here are of deoxyhaemoglobin versus deoxyhaemoglobin S, and you can see how a simple genetic mutation can cause an alteration in molecular structure. It is this transformation that causes the development of sickle cell disease.

Biochemistry case study 4 – sickle cell trait

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Content Author:
Keith Chambers, Leicester Royal Infirmary

Level:
Undergraduate science or medical student, trainee biomedical scientist

OER Features:

Word Doc Case Study – SCOOTER98a_Sickle_Trait_Case_Study

PDF File – SCOOTER98b_Sickle_Trait_Case_Study

OER Description:

Identification of sickle cell trait requires a combination of looking at blood cell morphology and biochemistry. This case study steps you through some important points to understand fully the characteristic of the blood. A solubility test may also be performed to provide a firm diagnosis.

Biochemistry case study 3 – sickle cell blood

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Content Author:
Keith Chambers, Leicester Royal Infirmary

Level:
Undergraduate science or medical student, trainee biomedical scientist

OER Features:

Word Doc Case Study – SCOOTER99a_Sickle_Cell_Disease_Case_Study

PDF File – SCOOTER99b_Sickle_Cell_Disease_Case_Study

OER Description:

These OER have been bundled up into a case study that would be a useful discussion-aid for bioscience or medical students. We may all be familiar with the morphology of the red blood cells in sickle cell anaemia, and this resource includes images of those alongside biochemical tests that would be carried out to further examine the patient.

Biochemistry case study 2 – neonate blood

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Neonate HPLC — Blood biochemistry – content kindly provided by Leicester Royal Infirmary

Content Author:
Keith Chambers, Biomedical Scientist at the Leicester Royal Infirmary

Level:
Undergraduate science or medical student, trainee biomedical scientist

OER Features:

Word Doc case study – SCOOTER97a_Neonate_Case_study

PDF File – SCOOTER97b_Neonate_Case_study

Image Bundle – Biochemistry Images

OER Description:

Neonatal blood is interesting and is visually different to adult blood. These resources would provide a useful case study for classroom discussions to highlight some of the morphological and biochemical differences. Neonatal blood contains different haemoglobin molecules, and a series of biochemical tests (iso-electic focusing and HPLC) are carried out to get a full and accurate profile of the blood.

Biochemistry case study 1 – adult blood

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SCOOTER96d_Healthy_Adult_IEF — Blood biochemistry – kindly provided by Keith Chambers of the Leicester Royal Infirmary

Content Author:
Keith Chambers, Biomedical Scientist at the Leicester Royal Infirmary

Level:
Undergraduate science or medical student, trainee biomedical scientist

OER Features:

Word Doc – SCOOTER96a_Healthy_Adult_Case_study

PDF File – SCOOTER96b_Healthy_Adult_Case_study

Image Bundle – Biochemistry Images

OER Description:

The Leicester Royal Infirmary provided significant amounts of content for our various OER projects, and resources that we created were subsequently used for our undergraduate teaching as well as to support their laboratory trainees. Win win! This one is part of a series of four biochemistry case studies.