The images here are of deoxyhaemoglobin versus deoxyhaemoglobin S, and you can see how a simple genetic mutation can cause an alteration in molecular structure. It is this transformation that causes the development of sickle cell disease.
Identification of sickle cell trait requires a combination of looking at blood cell morphology and biochemistry. This case study steps you through some important points to understand fully the characteristic of the blood. A solubility test may also be performed to provide a firm diagnosis.
These OER have been bundled up into a case study that would be a useful discussion-aid for bioscience or medical students. We may all be familiar with the morphology of the red blood cells in sickle cell anaemia, and this resource includes images of those alongside biochemical tests that would be carried out to further examine the patient.
Neonatal blood is interesting and is visually different to adult blood. These resources would provide a useful case study for classroom discussions to highlight some of the morphological and biochemical differences. Neonatal blood contains different haemoglobin molecules, and a series of biochemical tests (iso-electic focusing and HPLC) are carried out to get a full and accurate profile of the blood.
The Leicester Royal Infirmary provided significant amounts of content for our various OER projects, and resources that we created were subsequently used for our undergraduate teaching as well as to support their laboratory trainees. Win win! This one is part of a series of four biochemistry case studies.